Madonna is an American singer-songwriter and performer, recognized as the best-selling female recording artist of all time. She played Karen's roommate Liz.


Megan Mullally (Karen Walker) admitted in 2017 that Madonna did not know the cast's names except hers (Mullally's) during shooting, instead referred to the others by their character's names.


  • Shortly after shooting the episode and before it aired, Mullally hosted a special interviewing Madonna regarding the issues surrounding the music video of American Life (2003).

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