To Serve and Disinfect is the sixth episode of the second season and 28th overall.
- Eric McCormack (Will Truman)
- Debra Messing (Grace Adler)
- Sean Hayes (Jack McFarland)
- Megan Mullally (Karen Walker)
- Terry Kiser (Carl)
- Brian Palermo (Brian Kelly)
- Kim Robillard (Brent)
- Alex Boling (Stuart)
- Brian Jacobs (Cater-Waiter #5)
- Karen's maiden name is Delaney.
- Karen's fetish video is called "Next to Godliness." Scenes from the video were actually shot, but only the audio was aired.